如果你需要购买磨粉机，而且区分不了雷蒙磨与球磨机的区别，那么下面让我来给你讲解一下： 雷蒙磨和球磨机外形差异较大，雷蒙磨高达威猛，球磨机敦实个头也不小，但是二者的工
随着社会经济的快速发展，矿石磨粉的需求量越来越大，传统的磨粉机已经不能满足生产的需要，为了满足生产需求，黎明重工加紧科研步伐，生产出了全自动智能化环保节能立式磨粉
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要作用，近年来焦亡通过Caspase 激活的具体机制研究取得了突破性的进展，gasdermin D 蛋白(GSDMD)作为Caspase 底物被切割并发挥针对细胞膜的穿孔作用，诱导细胞焦亡，其
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2021年5月17日 最新研究发现，Gasdermin (GSDMs) 可诱导细胞凋亡向细胞焦亡转换，并可诱导炎症和抗肿瘤免疫。 GSDMs可由半胱天冬酶和颗粒酶激活，大多数在不同的情况下能诱导凋
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2024年4月26日 细胞焦亡是一种由gasdermin（GSDM）家族蛋白介导的程序性细胞死亡，在机体抵御病原感染、清除变异或有害细胞等过程中发挥重要作用。 作为细胞焦亡的直接执行
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全长GSDMB可以通过与其CARD结构域的相互作用激活Caspase4来诱导焦亡； 3GSDMC会被活化的Caspase8切割，产生活性N端片段，靶向细胞膜打孔，导致细胞发生焦亡； 4GSDMD
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发布时间：2023/03/31 北京生命科学研究所/清华大学生物医学交叉研究院邵峰团队在2020年发现，细胞毒性淋巴细胞分泌的颗粒酶A (GZMA) 特异地切割和活化靶细胞内gasdermin家族的成
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2020年4月17日，北京生命科学研究所/清华大学生物医学交叉研究院邵峰实验室在《Science》杂志在线发表题为“Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger
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GSDMs形成的孔洞会破坏膜的完整性，造成胞内物质，如炎症细胞因子释放到胞外空间，引起炎症性的细胞死亡，即细胞焦亡 （Pyroptosis）。 为更好地帮助大家了解细胞焦亡与常见的自
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2021年7月7日 研究发现，GSDMD可由caspase1/4,5/11激活，GSDME可由caspase3激活，GSDMB可由caspase3/6/7激活。 GSDMA是第一个GSDM家族成员，GSDMA3的表达可
2023年12月21日 被激活的GSDMs N端在质膜上穿孔，导致细胞裂解，引起细胞内的促炎分子及损伤相关分子模式（dangerassociated molecular patterns，DAMPs）迅速有效地从焦亡细胞
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摘 要：为了解白云母粉体超细磨过程的特点，对白云母超细磨产品进行了SEM、XRD、XPS和FTIR表征。 结果表明：当超细磨时间小于0．5h时，元素K的结合能漂移较大，白云母主要沿
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Mitochondrial association of GSDMs, measured via biochemical fractionation and immunofluorescence microscopy, has been observed for GSDMs in several cell types/conditions [30, 34, 67, 68] This association with mitochondrial membrane fractions has been seen for overexpressed GSDM fragments NT [ 69 ], as well as for endogenous GSDMD NT following
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2021年10月9日 虽然激活gsdms的生理刺激仍未知，但gsdms被发现可作为某些胞质蛋白酶的激活传感器，如半胱天冬酶、中性粒细胞弹性蛋白酶等。 由于在炎症发生中的重要作用， GSDMs激动剂或拮抗剂的研发将有可能改善炎症性疾病的治疗。
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The most important advance in our understanding of GSDM biology came in 2015 when two seminal articles simultaneously identified GSDMD as the primary executor of a type of proinflammatory programmed cell death known as pyroptosis (19, 20)Pyroptosis results from the formation of large numbers of GSDM pores that disrupt plasma membrane integrity, leading to
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2023年9月1日 More recent findings suggest that some GSDMs can drive additional cell death pathways, such as apoptosis and necroptosis, through mechanisms independent of plasma membrane perforation There is also emerging evidence that by associating with cellular compartments such as mitochondria, peroxisomes , endosomes, and the nucleus, GSDMs
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2023年3月29日 Gasdermins (GSDMs) are poreforming proteins that play critical roles in host defence through pyroptosis1,2 Among GSDMs, GSDMB is unique owing to its distinct lipidbinding profile and a lack of
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2021年9月2日 Consequently, the mRNA expression of all the six GSDMs was accordantly increased in HCC, while only the protein expressions of GSDMB, GSDMD, and GSDME were apparently increased in HCC tissue The expression of all the GSDMs (except GSDMA) was significantly higher in tumor stage 1–3 subgroups, compared with that in normal subgroups
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最可能与gsdms相关分子相关的三个信号通路是细胞粘附、生长调节和激素代谢过程。大多数gsdms成员与b细胞、中性粒细胞和树突状细胞的浸润呈正相关，而与巨噬细胞呈负相关。所有 6 名 gsdm 成员在 hcc 组织中均表现出显着降低的甲基化水平。
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在上述提到的几种途径中，我们不难发现，gsdms家族是细胞焦亡的关键所在。因为gsdms家族是细胞焦亡的执行分子，其打孔功能是细胞焦亡发生的必要条件。这个家族一般包含有一个细胞毒性的n末端结构域和一个c末端的抑制结构域。
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2021年11月3日 Six Gasdermins (GSDM) family members participate in various biological processes especially pyroptosis, as well as in the initiation and development of many types of cancer However, the systematic analysis of the GSDM family in hepatocellular carcinoma (HCC) is lacking In this study, several bioin
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2023年4月28日 （数据来源Broz P, et al Nat Rev Immunol 2020） GSDM功能机制 GSDM家族的所有成员（DFNB59除外）包含一个细胞毒性N末端结构域和一个由灵活接头连接的C末端阻遏物结构域，对两个结构域之间的蛋白切割位点
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2021年12月1日 GSDMs are cytoplasmic proteins (around 50 KDa) with nine conserved motifs (containing leucinerich regions) of still unknown function, distributed throughout the protein [3]GSDMs, with the exception of PJVK, share a moderately conserved Nterminal (NT) and Cterminal (CT) domains that are interconnected by a central hinge region, which is specific for
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2018年9月14日 Gasdermins (GSDMs) are a family of functionally diverse proteins which are expressed in a variety of cell types and tissues [1], [2], [3]Earlier identification of GSDMs in the gastrointestinal tract and dermis led to its nomenclature, “gasdermin” [4], [5]Six GSDMs are found in humans and 10 GSDMs are found in mice
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2024年4月22日 由于gsdms是一个新兴的研究领域，gsdms在炎症和相应疾病中的更具体功能仍有待阐明。 最近发现的gasdermin (GSDM)蛋白家族在调节焦亡(程序性细胞死亡
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2021年2月8日 Introduction Gasdermins (GSDMs) are a conserved family of functionally diverse proteins which are mainly expressed in the gastrointestinal (GI) tract, skin and immune cells (Xia et al, 2019)In human, the GSDM family includes six members, GSDMAE and PJVK (or autosomal recessive deafness type 59, DFNB59) (Van Laer et al, 1998; Delmaghani et al,
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2024年4月8日 GSDMs have been implicated in a range of diseases including, but not limited to, sepsis, viral infections, and cancer, either through involvement in pyroptosis or independently of this process
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gasdermin家族蛋白(gsdms)包括人类的6种蛋白gsdma、gsdmb、gsdmc、gsdmd、gsdme、dfnb59和小鼠的10种蛋白gsdma1～3、gsdmc1～4、gsdmd、gsdme、dfnb59，因最初被发现多表达于胃肠道和皮肤的上皮组织而得名 [1,2] 。 既往在基因、蛋白和动物模型等不同水平的研究表明gsdms可能参与了上皮细胞发育、凋亡、炎症、癌变及
2023年6月5日 Devant and Kagan review the biochemical and cell biological mechanisms that control gasdermin D poreforming activity and its diverse downstream immunological effects
2023年4月14日 GSDMs are activated by proteolytic removal of autoinhibitory carboxyterminal domains, typically by caspase regulators1–9 However, no activator is known for one member of this family, GSDMA
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2023年12月16日 Compared to other GSDMs, GSDME is more likely to act as a tumor inhibitor via activating pyroptosis and correlate with anticancer immunity Evidence shows that the absence of GSDME in tumors
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2024年1月5日 Gasdermins（GSDM）是一种由细胞质感知侵袭性感染和危险信号而引发的炎症性细胞死亡的介质。一旦被激活，GSDM形成细胞膜孔，释放促炎细胞因子和警报，破坏细胞膜的完整性，引发炎症细胞死亡。焦亡在体内是一个极其
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2021年8月4日 Gasdermins (GSDMs) are proteins primarily involved in pyroptosis, among other cellular functions This Review provides a comprehension summary of GSDM biology, focusing on the gastrointestinal
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Gasdermin (GSDM) 是由人类中的六个旁系同源基因编码的蛋白质家族，包括GSDMA、GSDMB、GSDMC、GSDMD、GSDME （也称为DFNA5 ）和DFNB59 （也称为pejvakin ）。在结构上，GSDM 家族成员拥有一个 C 末端（自动抑制结构域）和一个带正电荷的 N 末端（成孔结构域），通过不同的肽接头连接。
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2024年4月22日 由于gsdms是一个新兴的研究领域，gsdms在炎症和相应疾病中的更具体功能仍有待阐明。 最近发现的gasdermin (GSDM)蛋白家族在调节焦亡(程序性细胞死亡
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2022年4月22日 Moreover, neither of the functions of GSDMs revealed by these two studies are related to pyroptosis, which may provide new insights into the nonpyroptosisdependent functions of GSDM proteins
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2023年2月23日 GSDMs are abnormally expressed in breast cancer and are involved in cancer progression Pyroptosis is associated with inflammatory cytokine production, which exerts effects on cancer progression
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2023年4月14日 GSDMs are activated by proteolytic removal of autoinhibitory carboxyterminal domains, typically by caspase regulators1–9 However, no activator is known for one member of this family, GSDMA
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2023年6月5日 Devant and Kagan review the biochemical and cell biological mechanisms that control gasdermin D poreforming activity and its diverse downstream immunological effects
.jpg)
Mitochondrial association of GSDMs, measured via biochemical fractionation and immunofluorescence microscopy, has been observed for GSDMs in several cell types/conditions [30, 34, 67, 68] This association with mitochondrial membrane fractions has been seen for overexpressed GSDM fragments NT [ 69 ], as well as for endogenous GSDMD NT following
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2021年10月9日 虽然激活gsdms的生理刺激仍未知，但gsdms被发现可作为某些胞质蛋白酶的激活传感器，如半胱天冬酶、中性粒细胞弹性蛋白酶等。 由于在炎症发生中的重要作用， GSDMs激动剂或拮抗剂的研发将有可能改善炎症性疾病的治疗。
The most important advance in our understanding of GSDM biology came in 2015 when two seminal articles simultaneously identified GSDMD as the primary executor of a type of proinflammatory programmed cell death known as pyroptosis (19, 20)Pyroptosis results from the formation of large numbers of GSDM pores that disrupt plasma membrane integrity, leading to
.jpg)
2023年9月1日 More recent findings suggest that some GSDMs can drive additional cell death pathways, such as apoptosis and necroptosis, through mechanisms independent of plasma membrane perforation There is also emerging evidence that by associating with cellular compartments such as mitochondria, peroxisomes , endosomes, and the nucleus, GSDMs
2023年3月29日 Gasdermins (GSDMs) are poreforming proteins that play critical roles in host defence through pyroptosis1,2 Among GSDMs, GSDMB is unique owing to its distinct lipidbinding profile and a lack of
.jpg)
2021年9月2日 Consequently, the mRNA expression of all the six GSDMs was accordantly increased in HCC, while only the protein expressions of GSDMB, GSDMD, and GSDME were apparently increased in HCC tissue The expression of all the GSDMs (except GSDMA) was significantly higher in tumor stage 1–3 subgroups, compared with that in normal subgroups
.jpg)
最可能与gsdms相关分子相关的三个信号通路是细胞粘附、生长调节和激素代谢过程。大多数gsdms成员与b细胞、中性粒细胞和树突状细胞的浸润呈正相关，而与巨噬细胞呈负相关。所有 6 名 gsdm 成员在 hcc 组织中均表现出显着降低的甲基化水平。
.jpg)
在上述提到的几种途径中，我们不难发现，gsdms家族是细胞焦亡的关键所在。因为gsdms家族是细胞焦亡的执行分子，其打孔功能是细胞焦亡发生的必要条件。这个家族一般包含有一个细胞毒性的n末端结构域和一个c末端的抑制结构域。
.jpg)
2021年11月3日 Six Gasdermins (GSDM) family members participate in various biological processes especially pyroptosis, as well as in the initiation and development of many types of cancer However, the systematic analysis of the GSDM family in hepatocellular carcinoma (HCC) is lacking In this study, several bioin
